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A Missing Link in Healing Chronic Illness

Posted on March 30, 2014 at 2:05 AM

Do you sometimes feel that you have done everything possible to get well, yet your chronic illness still prevails? Replaced your mercury fillings? Removed your root canals? Juiced? Raw food vegan diet? Detoxed by every available technique? If you are running out of options, you might consider getting the MTHFR genetic test.

MTHFR is the acronym for methylene tetrahydrofolate reductase and this enzyme plays a key role in the process of methylation.  It impacts your ability to make glutathione, a pivotal antioxidant for detoxification.  People with MTHFR anomalies usually have low glutathione, which makes them more susceptible to stress and less tolerant to toxic exposures.  Accumulation of toxins in the body and increased oxidative stress will lead to fatigue, premature aging and chronic health problems.  People with MTHFR mutations have a reduced ability to eliminate toxins and heavy metals, including mercury.

MTHFR genetic defects affect at least 40% of the population.  Having the mutation does not necessarily mean that you will show symptoms or develop conditions associated with MTHFR.  How the MTHFR genes express themselves can have a lot to do with a person’s nutrition, stress level, environmental factors and other genetic mutations. This may explain why two people can have the same MTHFR mutation and not be affected equally.

 Some conditions that may be associated with MTHFR gene mutations

  • Autism
  • Addictions: smoking, drugs, alcohol
  • Down’s syndrome
  • Frequent miscarriages
  • Male & female infertility
  • Pulmonary embolism and other blood clots
  • Depression & anxiety
  • Schizophrenia
  • Bipolar disorder
  • Fibromyalgia
  • Chronic Fatigue Syndrome
  • Chemical Sensitivity
  • Parkinson’s disease
  • Irritable Bowel Syndrome
  • Stroke
  • Spina bifida
  • Migraines
  • Hyperhomocysteinemia
  • Breast cancer
  • Atherosclerosis
  • Alzheimer’s
  • Multiple Sclerosis
  • Myocardial Infarction (Heart Attack)
  • Nitrous Oxide Toxicity

Although there are over fifty known MTHFR variants, the two primary ones are called C677T and A1298.  Your medical doctor can order a blood test to determine if you have these genetic variants. Or, you can order a complete genetic profile yourself through 23andMe.  And if you find that you have the genetic mutation, you might suggest other family members to be tested, especially if they have any of conditions listed above.

Treatment for MTHFR mutations involves a special diet with nutritional supplementation.

More information can be found at this website to further your understanding of MTHFR ; .

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Categories: Detoxification, Healing, Mercury

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Reply Fran
10:45 PM on November 8, 2015 
This article was a real eye opener for me. Thank you for writing it.
Reply Angela
4:52 PM on May 3, 2016 
Dr. Brand,
Thank you for posting on this issue. My almost 3 year old son has early childhood caries. His teeth are badly decayed and we have been to several dentists, 4 flouride treatments, and now we have to act. Our son was recently diagnosed with compound heterozygous MTHFR. We know that nitrous oxide can be toxic so he will be having IV sedation. If the doctor suggests root canals, should we proceed with that treatment? Everything I am finding on the internet suggests that root canals are a bad idea with someone who has this gene mutation. Any advice you are able to give on this subject would be greatly appreciative. Thank you for your time.

Reply Dr. Brand
5:41 PM on May 3, 2016 
Hi Angela,
Root canals are a bad for anyone, regardless of the MTHFR factor. If the dentist cannot save the tooth (maybe by pulp capping), it might be best to extract the tooth and get a space maintainer. It is always best to get a 2nd opinion before any root canal, but that may be difficult in this situation since your child will be under general anesthesia.
Reply Angela
3:15 PM on May 4, 2016 
Thank you for your quick reply, Dr. Brand. The previous dentist told us that several teeth would need root canals. I think that I will follow what my gut is telling root canals! I have always been anti flouride, but the previous dentist said that it would halt the decay. I wish I would have followed my gut instincts then. It seems like his teeth decayed at a quick rate after the flouride treatments. :(
Wish you were on the West Coast. Great website!
Reply Angela
3:58 PM on May 4, 2016 
Sorry, Dr. more question.
Is pulp capping the same as a pulpotomy?
Reply Dr. Brand
10:22 PM on May 4, 2016 
Pulp capping and pupotomy are similar in that they both involve treating the nerve without doing a root canal. This is a good choice when the decay is deep and the nerve is involved. It can be very successful with primary (baby) teeth. This link may explain more.